1952 (flat out filled with 'em) - Pete Runnels, Minnie Minoso, Dick Groat and Joe "the old lefthander" Nuxhall.
1959 - Felipe Alou, Norm Cash, Jim Perry.
1963 (though I hate the floating head cards) - Tony Oliva and Bill Freehan (tie); Rusty Staub and Dave McNally (Honorable Mention).
1964 - Mickey Lolich and Tommy John (tie); Tony Conigliaro, Willie Horton, Tony LaRussa, Richie Allen and "Sweet Lou" Pinella (Honorable Mention).
1965 - Luis Tiant with Mel Stottlemyre Honorable Mention and Denny McLain DIS-Honorable Mention.
1966 (weak year for rookies) - Bobby Murcer with George Scott Honorable Mention.
1967 - Joe Niekro with Mark Belanger Honorable Mention.
That about covers the years I care about.
#1 in 1959 Topps